CERSI P.I.s and Collaborators: Matthew Trudeau, Ph.D., Ashley Johnson, Ph.D.
FDA SMEs and Collaborators: Wendy Wu, Ph.D., David Strauss, Ph.D., CDER


Project Overview

The scope of work is to perform applied regulatory research in ion channel pharmacology. The Trudeau lab will collaborate with the FDA as part of the Comprehensive in-vitro Proarrhythmia Assay (CiPA) initiative. Our part of the collaboration will be to measure dose-response curves of 7 different drugs (at 4 different concentrations) that inhibit hERG (KCNH2) potassium channels, expressed in stably transfected HEK293 cells using whole-cell patch-clamp electrophysiology at physiological temperatures. Dr. Matthew Trudeau of the University of Maryland, Baltimore is contributing to this research, along with FDA collaborators David Strauss, Ruth Barratt, Wendy Wu, and Zhihua Li.