Biofabricating an Interface Between Biology and Electronics
Monday, November 25, 2013
2:00 p.m.-3:00 p.m.
FDA WO Campus, Bldg. 2 room 2047E
Seminar by Gregory F. Payne, Professor
Institute for Bioscience and Biotechnology Research and
Fischell Dept. of Bioengineering
University of Maryland, College Park
Gregory F. Payne received his B.S. and M.S. degrees in Chemical Engineering from Cornell University in 1979 and 1981, respectively. He received his Ph.D. in Chemical Engineering from The University of Michigan in 1984. After completing his Ph.D., he returned to Cornell to do post-doctoral work with Michael Shuler in biochemical engineering. In 1986 Prof. Payne joined the faculty of the University of Maryland where he is currently a Professor jointly-appointed in the Institute for Bioscience and Biotechnology Research and the Fischell Department of Bioengineering. His research is focused on biofabrication the use of biological or biomimetic materials and mechanisms to confer structure and function to materials. Specifically, his group biofabricates using enzymes and biologically-derived polymers such as chitosan. Prof. Payne has published over 130 peer-reviewed journal papers, been awarded 6 US patents, served on the advisory board of numerous international symposia and study sections, and received the University of Maryland Regents Award for research, scholarship and creative activity. Currently, he spends 6 months per year in China where he is Guest Professor at Wuhan University and Chair Professor at East China University of Science and Technology.
Advances in biology and microelectronics transformed our lives over the last 50 years and there remains considerable opportunity to create synergies between these two fields. For instance, the effective interfacing of biological and electronic systems could enable remarkable capabilities for sensing (disease diagnosis and monitoring), energy harvesting (biofuel cells) and medicine (neuroprosthetics). Through a network of local and international collaborations, we are examining two challenges to bio-device integration constructing the physical interface and establishing communication across this interface. In both cases, we are applying the materials and mechanisms from biology to address these challenges.
To construct a bio-device interface we employ stimuli-responsive hydrogel-forming biopolymers (especially polysaccharides) that can be triggered to self-assemble at electrode addresses in response to electrode-imposed signals. The hydrogel films assembled at the electrode can be bio-functionalized to offer cellular functions or modified with proteins to offer molecular functions. Communication across this interface is achieved through redox. Specifically a redox-active (but non-conducting) film is fabricated to accept redox information from biology and transmit this information to the electronics. These studies demonstrate that biology offers unique materials and mechanisms for the fusion of biology and electronics.