BIOE Seminar: Roger Kamm (MIT)
Friday, March 29, 2019
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Dr. Giuliano Scarcelli
Dr. Roger Kamm
Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering
Massachusetts Institute of Technology
Microphysiological models that rely on emergence: Applications to metastatic cancer and neurological disease
Recent work from many labs has demonstrated the unique capability of cells placed in 3-dimensional culture to self-organize into functional units and organ-like systems. In some cases, aggregates of pluripotent stem (IPS) cells can be induced to differentiate down independent pathways, leading to an organoid. In others, interacting units of multiple cell phenotypes can be generated, often from iPS cells, and ‘engineered’ to interact in a way that recapitulates certain aspects of in vivo function or disease. Such models have tremendous potential both as a means to gain new insight into disease processes and for use in moderate throughput (100-1000 agents) drug screening. In this talk I will describe models developed in our lab 1) to simulate cancer metastasis in a remote organ, 2) to screen for ALS drugs in a model motor unit, and 3) to simulate transport across the blood-brain barrier, addressing some of the design principles they have in common, their future potential, and barriers to progress.
About the Speaker
Kamm’s interests lie at the interface of biology and mechanics, with research in cell and molecular mechanics, and more recently in micro-physiological systems to model cancer and neurodegenerative disease. Kamm has fostered biomechanics as Chair of the US National Committee on Biomechanics and of the World Council on Biomechanics and currently directs the NSF Center on Emergent Behaviors of Integrated Cellular Systems. He is a recipient of the Lissner Medal and the the Huiskes Medal, both for lifetime achievements, and is the inaugural recipient of the Nerem Medal for mentoring and education. He is a member of the National Academy of Medicine since 2010. Kamm is founder of AIM Biotech, a company that markets microfluidics for 3D cell culture systems.