CERSI Lecture Role and Relevance of Proton-Coupled Oligopeptide Transporters in the Brain

Monday, June 26, 2017
1:30 p.m.-2:30 p.m.
FDA White Oak Campus, Silver Spring, MD 20993
Ann Anonsen
301 405 0285

David E. Smith, Ph.D.
John G. Wagner Collegiate Professor of Pharmaceutical Sciences
University of Michigan 

To view the seminar please access the following recording link: https://collaboration.fda.gov/p9og5myunqc/ 

Role and Relevance of Proton-Coupled Oligopeptide Transporters in the Brain

You are invited to attend the next lecture of FDA’s 2017 CERSI Lecture Series (link is external) on Monday, June 26, 2017, at 1:30 – 2:30 pm EST via webinar. University of Maryland CERSI is the host and their guest speaker is David E. Smith, PhD, who will present on: "Role and Relevance of Proton-Coupled Oligopeptide Transporters in the Brain.”  Additional information provided below.


About the Speaker

 Dr. Smith is the John G. Wagner Collegiate Professor of Pharmaceutical Sciences at the University of Michigan, College of Pharmacy, and a member of the Comprehensive Cancer Center and Michigan Gastrointestinal Peptide Research Center in the School of Medicine.  He served as Founding Chair, Department of Pharmaceutical Sciences, from 1999-2010.  Dr. Smith received his B.S. in Pharmacy (1975) from the State University of New York at Buffalo and his Ph.D. in Pharmaceutical Chemistry (1981) from the University of California San Francisco.  Upon completing his doctoral thesis, he joined the faculty at the University of Michigan as an Assistant Professor of Pharmacy.     Dr. Smith is a Fellow of the American Association of Pharmaceutical Scientists (1998) and the American Association for the Advancement of Science (2012), and served on the Pharmacology Study Section of the National Institutes of Health (1998-2002).  He received the James R. Gillette Drug Metabolism and Disposition Best Paper Award from the American Society for Pharmacology and Experimental Therapeutics on two separate occasions (2002 and 2008).  In 2003, he received both the College of Pharmacy Teaching Excellence Award and the Student Appreciation Award.  Dr. Smith is a member of several scientific and professional organizations (e.g., AAAS, AACP, AAPS, APhA, ASPET, ISSX) and is an Editor of Pharmaceutical Research.  During his career, he has made many important scientific contributions, including those on the kinetic-dynamic relationship of loop diuretics, the determinants of renal drug elimination, the regional pharmacokinetics of anticancer drugs, and the cellular and molecular biology, physiology and pharmacology of proton-coupled oligopeptide transporters. 


Lecture Abstract

Drug transporters have been widely studied for their physiological, pharmacological and toxicological relevance in select organs for improved delivery and targeting of substrates in the intestine, kidney, liver and brain.  Some of these transporters, however, make drug delivery to these organs more difficult because of their role in efflux as opposed to influx.  In this presentation, I will give a general overview of drug transporters in the brain and, more specifically, to our newest research on the role and relevance of proton-coupled oligopeptide transporters (PepT2 and PhT1) in this sanctuary tissue. 


Remote Access Information

URL:    https://collaboration.fda.gov/cersi6-26/

TELECONFERENCE NUMBER: 301-796-7777 passcode: 665106

For questions please contact Lei Zhang at leik.zhang@fda.hhs.gov

This Event is For: Public

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