Top-Down Analysis of Antibodies
Friday, June 20, 2014
8:45 a.m.-6:00 p.m.
University of Maryland Baltimore School of Pharmacy
Antibodies are a class of proteins that are key to immunological defense systems. One of the most popular drug candidates in recent years, there are approximately 30 monoclonal antibodies (MAbs) currently used in human therapeutics, and their characterization has drawn increasing attention. Top-down protein analysis using mass spectrometry measures proteins in their intact form, as well as any "proteoforms." However, this technique could also provide more efficient identification of post-translational modifications (PTMs).
This conference will deliver clear outcomes that benefit the scientific community with up-to-date, state-of-the-art mass spectrometry-based applications to interrogate antibodies, including therapeutic MAbs.